AnatomyIntermediate2D simulation~15 min

Human Heart and Blood Circulation

Your heart beats about 100,000 times a day, pushing blood through two loops: one to the lungs to collect oxygen, and one to the rest of the body to deliver it. Watch the chambers squeeze, see the valves open and shut, and follow a single blood cell all the way round.

Diastole Click a chamber, valve or vessel
t = 0.0 s
72

Beats per minute. A typical resting adult rate is 60–100.

70

Blood pumped out of each ventricle per beat.

Key

  • Oxygenated blood
  • Deoxygenated blood
  • Open valve
  • Closed valve
  • Tracked blood cell
Phase of the heartbeat
—
Heart rate
—
Cardiac output (rate × stroke volume)
—
Tracked cell is in
—
Beats
—

How to use this simulator

  1. Watch the phase bar at the top right and the panel text: atria contract, then ventricles, then the heart relaxes.
  2. Turn on Slow motion to see the valves (white when open, yellow when shut) and hear where “lub” and “dub” come from.
  3. Keep Follow one blood cell on and read the Tracked cell is in readout to trace the full route.
  4. Use Asleep, Resting and Running, or the sliders, to change heart rate and stroke volume and watch the cardiac output change.
  5. Click any chamber, valve or vessel to learn what it does.

Structure of the heart

The heart is a muscular pump about the size of a fist, sitting between the lungs. It has four chambers: twoatria on top that receive blood, and two ventricles below that pump it out. A wall called the septum separates the right side (deoxygenated blood) from the left side (oxygenated blood). Diagrams show the heart as if you were facing the person, so the right side of the heart appears on the left of the picture.

Four valves keep blood moving one way. The tricuspid and mitral(bicuspid) valves sit between each atrium and ventricle. The pulmonary and aorticvalves sit where blood leaves the ventricles.

The pathway of blood

  1. Deoxygenated blood from the body returns through the venae cavae to the right atrium.
  2. It passes through the tricuspid valve into the right ventricle.
  3. The right ventricle pumps it through the pulmonary valve into the pulmonary artery and on to the lungs.
  4. In the lung capillaries it picks up oxygen and gives up carbon dioxide.
  5. Oxygenated blood returns through the pulmonary veins to the left atrium.
  6. It passes through the mitral valve into the left ventricle.
  7. The left ventricle pumps it through the aortic valve into the aorta, which branches to every organ.

Double circulation

Mammals and birds have a double circulation: blood passes through the heart twice on each full trip. The pulmonary circuit carries blood between the heart and lungs at low pressure, which protects the delicate lung capillaries. The systemic circuit carries blood to the rest of the body at high pressure, so it can reach the brain, the feet and everywhere between. That is why the left ventricle has a much thicker muscular wall than the right.

The cardiac cycle

Each heartbeat follows the same sequence. In atrial systole the atria contract, topping up the ventricles. In ventricular systole the ventricles contract: the pressure rise slams the tricuspid and mitral valves shut (the first heart sound, “lub”) and forces the pulmonary and aortic valves open. Indiastole the muscle relaxes, the pulmonary and aortic valves shut (the second sound, “dub”), and blood flows in from the veins to refill the chambers. The beat is started by the heart’s own pacemaker, thesinoatrial node, in the wall of the right atrium.

Heart rate and cardiac output

Cardiac output is the volume of blood each ventricle pumps per minute:

cardiac output = heart rate × stroke volume

At rest, 70 beats per minute × 70 mL ≈ 4.9 L per minute: roughly all of your blood every minute. During hard exercise, adrenaline and nerve signals raise both the rate and the strength of each beat, and output can reach 15–20 L per minute in a fit adult, or more in trained athletes.

Arteries, veins and capillaries

  • Arteries carry blood away from the heart. They have thick, elastic, muscular walls to cope with high pressure.
  • Veins carry blood back to the heart at low pressure. They have thinner walls and valves to stop backflow.
  • Capillaries are only one cell thick, so oxygen, nutrients and waste can pass between blood and tissues.

Key terms

Atrium / ventricle
Upper receiving chamber / lower pumping chamber of the heart.
Systole / diastole
Contraction / relaxation of the heart muscle.
Stroke volume
Volume of blood pumped by one ventricle in one beat.
Septum
Muscular wall dividing the left and right sides of the heart.

Common misconceptions

  • “Arteries always carry oxygenated blood.” The pulmonary artery carries deoxygenated blood. Arteries are defined by direction: away from the heart.
  • “Deoxygenated blood is blue.” It is dark red. Blue is just a diagram convention.
  • “The two sides of the heart beat one after the other.” Left and right contract together; it is the atria and ventricles that take turns.

Educational model only. This simulator is a simplified diagram, not a medical tool. It cannot diagnose or assess any heart condition, and the values shown are typical textbook figures. If you have concerns about your heart or health, speak to a qualified healthcare professional. See our educational and medical disclaimer.

Key takeaways

  • The right side of the heart pumps blood to the lungs; the left side pumps it to the body.
  • Valves keep blood flowing one way and make the “lub-dub” sounds as they shut.
  • Each beat is atrial systole, ventricular systole, then diastole.
  • Cardiac output = heart rate × stroke volume.

Model note: the diagram is schematic, not to scale, and the vessels are rearranged so the two circuits are easy to follow. One trip round the loop takes about 8 beats here; in a resting person it takes about a minute.

Knowledge check

Human Heart and Blood Circulation: test your understanding

Answer each question to get instant feedback and an explanation. Use the simulator to check your thinking.

8 questions3 basic3 intermediate2 advanced

0 of 8 answered

  1. Q1BasicWhich chamber of the heart pumps blood to the whole body?
    Show answer

    Answer: D. Left ventricle

    The left ventricle pumps oxygenated blood into the aorta, which branches to supply the whole body.

  2. Q2BasicWhich blood vessel carries deoxygenated blood from the heart to the lungs?
    Show answer

    Answer: B. Pulmonary artery

    The pulmonary artery leaves the right ventricle. Arteries carry blood away from the heart, whether or not it is oxygenated.

  3. Q3BasicWhat is the main job of the heart valves?
    Show answer

    Answer: B. To stop blood flowing backwards

    Valves open to let blood through in one direction and shut to stop it flowing back, as you can see in the simulator.

  4. Q4IntermediateWhy is the wall of the left ventricle much thicker than the wall of the right ventricle?
    Show answer

    Answer: B. It must pump blood at higher pressure all around the body, while the right ventricle only pumps to the nearby lungs

    Both ventricles pump the same volume, but the systemic circuit needs much higher pressure (about 120 mmHg versus about 25 mmHg).

  5. Q5IntermediateThe first heart sound, “lub”, is caused by…
    Show answer

    Answer: B. The tricuspid and mitral valves closing

    When the ventricles start to contract, the atrioventricular valves snap shut (“lub”). The “dub” is the semilunar valves closing as the ventricles relax.

  6. Q6IntermediateA person’s heart rate is 70 beats per minute and their stroke volume is 70 mL. What is their cardiac output?
    Show answer

    Answer: C. About 4.9 L per minute

    Cardiac output = heart rate × stroke volume = 70 × 70 mL = 4,900 mL, or about 4.9 L, per minute.

  7. Q7AdvancedWhy do mammals have a double circulation?
    Show answer

    Answer: A. So blood passes through the heart twice per circuit, keeping pressure high for the body after the low-pressure trip through the lungs

    Blood loses pressure in the delicate lung capillaries. Returning to the heart lets the left ventricle re-pressurise it before sending it to the body.

  8. Q8AdvancedDuring exercise, cardiac output rises from about 5 to 15 L per minute. In the simulator, which two settings achieve this?
    Show answer

    Answer: B. Raising both heart rate and stroke volume

    The nervous system and adrenaline speed up the heart and make each beat stronger, so both factors in rate × volume increase.

References and further reading

  1. Betts, J. G., et al. (2022). Anatomy and Physiology 2e, Section 19.1: Heart Anatomy. OpenStax. openstax.org (opens in a new tab)
  2. Betts, J. G., et al. (2022). Anatomy and Physiology 2e, Section 19.3: Cardiac Cycle. OpenStax. openstax.org (opens in a new tab)
  3. Betts, J. G., et al. (2022). Anatomy and Physiology 2e, Section 19.4: Cardiac Physiology. OpenStax. openstax.org (opens in a new tab)
  4. Hall, J. E., & Hall, M. E. (2020). Guyton and Hall Textbook of Medical Physiology (14th ed.). Elsevier.

This page is an educational model, not medical advice. Found an error? Let us know. See our educational disclaimer.